Papers of Thomas Lee Settle (1836-1920), physician, and surgeon of the 11th Virginia Cavalry, C.S.A., include orders for the Virginia militia, 1797 and 1800; family letters to Texas, Missouri, and Tennessee; and correspondence concerning the education of the Settle children and friends at various schools and academies in Virginia, and at Virginia Military Institute, Lexington, Virginia. Civil War correspondence, including letters of Captain Robert H. Simpson and other Confederate soldiers, describes the battles of first Manassas, Chickahominy Swamp, and Fredericksburg, the Peninsular Campaign, crops and conditions in northern Virginia during the war, and directions for making salt. There are also records of land sales, deeds, and rent receipts; medical correspondence, prescriptions, and bills; bills and receipts for land transactions, household expenses, and apple brandy making; horse-dealing records during the Civil War; two Confederate Loan Bonds; business papers of A. H. Settle & Co., merchants of Paris, Virginia, medical diary, 1855-1858, 1861, and 1865-1866, of Thomas Lee Settle; and a diary, 1863-1864, of Thomas Lee Settle describing his activities as surgeon to the 11th Virginia Cavalry. A journal, 1863, of John S. Timberlake entitled "Trip to Florida and Salt Works, Oct. 20, 1863. With descriptions of the country and other particulars intervening on the way," contains detailed descriptions of various salt works in Georgia; "Descriptions of Florida and Health and Other Particulars (useful) as they Happen" discussing health and agricultural conditions, sugar making, and the economic conditions of Florida and Georgia plantations; and a synopsis of Adiel Sherwood's 1860 Gazetteer of Georgia. Postwar materials include Sunday school record book, 1884; letters from soldiers in the Spanish-American War discussing camp life in Florida, the Rough Riders, courts-martial, and desertion; letter, 1909, from T. C. Evans, dean of the Medical Department, University of Louisville, Louisville, Kentucky discussing his department; letters from Edgar Ackley Moore (d. 1924), physician, to his wife Pauline (Settled Moore, daughter of Thomas Lee Settle, while serving in the U.S. Army Medical Reserve Corps during World War I, describing camp life and his experiences in America and France, the work of the Young Men's Christian Association and the American National Red Cross in France, casualties, prisoners, hospitals, and physicians; papers relating to Moore's Masonic affiliation; ledger, 1905-1907, and accounts, 1906-1912, of Edgar Ackley Moore; literary reviews; medical pamphlets; and scrapbooks and exercise books. Volumes consist of medical visiting and account books, 1855-1914, commonplace books, 1852-1867, daybook, 1901-1905, expense book, 1870-1880, ledgers, 1867-1913, and record book, 1856-1857, of Thomas Lee Settle; account book for the John Horn estate; pamphlets, including one on the San Francisco earthquake of 1906 and another on a silver mining scheme in Canada, entitled Julian Hawthorne and Company (1909); a stallion service book; and photographs. Other papers include genealogical information, original poetry, and legal documents and wills.